Abstract
Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety concerns. Administration of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side effects. We therefore designed and synthesized a library of hybrid molecules incorporating an imidazo[1,2-a]pyridine and an urea moiety as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors. Evaluation of the compounds was accomplished by in vitro testing using recombinant enzyme assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arachidonate 5-Lipoxygenase / chemistry*
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Epoxide Hydrolases / antagonists & inhibitors*
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Epoxide Hydrolases / chemistry
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Lipoxygenase Inhibitors / chemical synthesis*
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Lipoxygenase Inhibitors / chemistry
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Recombinant Proteins / chemistry
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Structure-Activity Relationship
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Urea / analogs & derivatives*
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Urea / chemical synthesis*
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Urea / chemistry
Substances
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Imidazoles
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Lipoxygenase Inhibitors
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Pyridines
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Recombinant Proteins
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Urea
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Arachidonate 5-Lipoxygenase
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Epoxide Hydrolases